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Tg(SMN2)566Ahmb
Transgene Detail
Nomenclature
Symbol: Tg(SMN2)566Ahmb
Name: transgene insertion 566, Arthur H M Burghes
MGI ID: MGI:2676920
Transgene: Tg(SMN2)566Ahmb  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SMN2)566Ahmb expresses 1 gene
 
Mutation detailsA 35.5 kb genomic fragment containing human SMN2 used for the transgene. The transgene is ubiquitously expressed in all tissues examined by Northern blot analysis. Line 566 carries 8 copies of the transgene. (J:60592)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Line 89 was also produced.
References
Original:  J:60592 Monani UR, et al., The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12;9(3):333-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory