Map3k1^tm1Yxia
Targeted Allele Detail

Summary

• Symbol: Map3k1^tm1Yxia
• Name: mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Ying Xia
• MGI ID: MGI:2676654
• Synonyms: Map3k1^deltaKD, Mekk1^deltaKD
• Gene: Map3k1 Location: Chr13:111882962-111945527 bp, - strand Genetic Position: Chr13, 63.36 cM
• Alliance: Map3k1^tm1Yxia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85346
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A small part of the coding sequence for the regulatory domain and all of the sequence for the C-terminal catalytic domain were replaced by LacZ and a neomycin resistence gene. MEKK1 kinase activity was reduced in heterozygous ES cells and no activity was present in homozygous ES cells. (J:85346, J:85791)

Expression

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k1 Mutation: 62 strains or lines available

References

• Original: J:85346 Zhang L, et al., A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 1;22(17):4443-54
• All: 28 reference(s)