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Targeted Allele Detail
Symbol: Map3k1tm1Yxia
Name: mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Ying Xia
MGI ID: MGI:2676654
Synonyms: Map3k1deltaKD, Mekk1deltaKD
Gene: Map3k1  Location: Chr13:111746428-111808993 bp, - strand  Genetic Position: Chr13, 63.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:85346
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA small part of the coding sequence for the regulatory domain and all of the sequence for the C-terminal catalytic domain were replaced by LacZ and a neomycin resistence gene. MEKK1 kinase activity was reduced in heterozygous ES cells and no activity was present in homozygous ES cells. (J:85346, J:85791)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 33 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k1 Mutation:  33 strains or lines available
Original:  J:85346 Zhang L, et al., A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 1;22(17):4443-54
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory