Stk11^tm1.1Jish
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.1Jish
• Name: serine/threonine kinase 11; targeted mutation 1.1, Kou-ichi Jishage
• MGI ID: MGI:2676546
• Synonyms: Lkb1^-
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.1Jish page

Growth retardation, impaired embryo turning and small somites in Stk11^tm1.1Jish/Stk11^tm1.1Jish embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77213
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The floxed sequence of Stk11^tm1Jish, encompassing exons 2 through 8, was excised via cre-mediated recombination in the germline. (J:77213)

Generation of the Stk11^tm1Jish and Stk11^tm1.1Jish alleles

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1.1Jish

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 34 strains or lines available

References

• Original: J:77213 Jishage K, et al., Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8903-8
• All: 1 reference(s)