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Targeted Allele Detail
Symbol: Stk11tm1.1Jish
Name: serine/threonine kinase 11; targeted mutation 1.1, Kou-ichi Jishage
MGI ID: MGI:2676546
Synonyms: Lkb1-
Gene: Stk11  Location: Chr10:80115803-80130682 bp, + strand  Genetic Position: Chr10, 39.72 cM
Growth retardation, impaired embryo turning and small somites in Stk11tm1.1Jish/Stk11tm1.1Jish embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77213
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe floxed sequence of Stk11tm1Jish, encompassing exons 2 through 8, was excised via cre-mediated recombination in the germline. (J:77213)
Generation of the Stk11tm1Jish and Stk11tm1.1Jish alleles
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  6 strains or lines available
Original:  J:77213 Jishage K, et al., Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8903-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory