Pkd2^tm1Dwo
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1Dwo
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1, Bernd Dworniczak
• MGI ID: MGI:2676373
• Synonyms: Pkd2^-/-lacZ+/+, Pkd2^tm1Blum
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1Dwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77401
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and a portion of intron 1 were replaced with a cassette containing lacZ and PGK-neo. Transcript was undetected in homozygous mutant embryos at E16.5 by Northern blot analysis. (J:77401)

Disease models

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 84 strains or lines available

References

• Original: J:77401 Pennekamp P, et al., The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol. 2002 Jun 4;12(11):938-43
• All: 3 reference(s)