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Gene trapped Allele Detail
Symbol: PitpnaGt(OST1152)Lex
Name: phosphatidylinositol transfer protein, alpha; gene trap OST1152, Lexicon Genetics
MGI ID: MGI:2676301
Synonyms: PITPalpha::neo/puro, PitpnaGt(VICTR20)1Vab
Gene: Pitpna  Location: Chr11:75588097-75628804 bp, + strand  Genetic Position: Chr11, 45.92 cM
Mutant Cell Line:  OST1152 (Lexicon Genetics)
Germline Transmission:  Earliest citation of germline transmission: J:85204
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
Mutation detailsA gene trap vector consisting of LTR sites flanking a beta-geo cassette containing a splice acceptor and a PGK-puro cassette containing a splice donor integrated into intron 7. Truncated protein product was undetected by Western blot analysis of homozygous mutant mice. (J:85204)
Inheritance:    Recessive
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitpna Mutation:  54 strains or lines available
Original:  J:85204 Alb JG Jr, et al., Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29;278(35):33501-18
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory