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Targeted Allele Detail
Symbol: Drd2tm2Ebo
Name: dopamine receptor D2; targeted mutation 2, Emiliana Borrelli
MGI ID: MGI:2675755
Synonyms: D2-, D2L -
Gene: Drd2  Location: Chr9:49340627-49408177 bp, + strand  Genetic Position: Chr9, 26.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:77277
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 6 was replaced with a neomycin selection cassette in order to selectively delete the long isoform of the receptor expressed from this gene. RNAse protection assays demonstrated that the short isoform expression is up-regulated in homozygotes and long isoform expression is undetectable. (J:77277)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  52 strains or lines available
Original:  J:77277 Usiello A, et al., Distinct functions of the two isoforms of dopamine D2 receptors. Nature. 2000 Nov 9;408(6809):199-203
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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