Synpo^tm1Mndl
Targeted Allele Detail

Summary

• Symbol: Synpo^tm1Mndl
• Name: synaptopodin; targeted mutation 1, Peter Mundel
• MGI ID: MGI:2675703
• Synonyms: synpo^-, Synpo^tm1Mif
• Gene: Synpo Location: Chr18:60727045-60793214 bp, - strand Genetic Position: Chr18, 34.36 cM
• Alliance: Synpo^tm1Mndl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85310
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region has been replaced by a lacZ gene fused in frame just downstream of the ATG start codon. A neomycin resistance gene flanked by loxP sites was then inserted downstream of lacZ. Lack of the protein product was then confirmed by Western blot analysis and by immunostaining. (J:85310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Synpo Mutation: 36 strains or lines available

References

• Original: J:85310 Deller T, et al., Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10494-9
• All: 14 reference(s)