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Noxo1hslt
Spontaneous Allele Detail
Nomenclature
Symbol: Noxo1hslt
Name: NADPH oxidase organizer 1; head slant
MGI ID: MGI:2675672
Gene: Noxo1  Location: Chr17:24696234-24700529 bp, + strand  Genetic Position: Chr17, 12.49 cM, cytoband A3.3
Vestibular defect causing tilting of the head in Noxo1hslt/Noxo1hslt mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  SJL.Cg-Thy1a
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsThe molecular lesion in the head slant mouse is a single insertion of a deoxyadenosine residue into exon 1, 28 nucleotides from the start codon. This frameshift mutation is predicted to result in a truncation of the encoded protein after the 34th amino acid. In addition, the transgenic expression of the wild-type gene rescued the defects in the homozygous mutant mouse. (J:106332)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Noxo1 Mutation:  4 strains or lines available
References
Original:  J:86035 Gagnon L, et al., A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt). Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2003;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory