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Nfkb2tm1Rsch
Targeted Allele Detail
Nomenclature
Symbol: Nfkb2tm1Rsch
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Roland Schmid
MGI ID: MGI:2675476
Synonyms: Nf-kb2-, p52-
Gene: Nfkb2  Location: Chr19:46304737-46312090 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77049
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.5 kb genomic fragment containing exons 1b through 9 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the initiator methionine and a portion of the Rel homology domain. Protein was undetected in homozygous mutant mice by Western blot analysis of spleen whole-cell protein extracts and a supershift analysis of spleen nuclear extracts. (J:77049)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:  25 strains or lines available
References
Original:  J:77049 Paxian S, et al., Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Gastroenterology. 2002 Jun;122(7):1853-68
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory