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Traf6tm1Jino
Targeted Allele Detail
Nomenclature
Symbol: Traf6tm1Jino
Name: TNF receptor-associated factor 6; targeted mutation 1, Jun-ichiro Inoue
MGI ID: MGI:2675469
Synonyms: TRAF6-, TRAF6KO
Gene: Traf6  Location: Chr2:101678429-101701669 bp, + strand  Genetic Position: Chr2, 53.9 cM
Abnormal phenotypes in skin and hair of Traf6tm1Jino/Traf6tm1Jino mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77453
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.5 kb genomic fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region corresponded with nucleotides 556 through 865 of the cDNA. Protein was undetected by Western blot analysis of brain lysates obtained from homozygous mutant mice. (J:77453)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Traf6 Mutation:  6 strains or lines available
References
Original:  J:77453 Naito A, et al., Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells. 1999 Jun;4(6):353-62
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/13/2020
MGI 6.16
The Jackson Laboratory