Ptch1^tm1Bjw
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm1Bjw
• Name: patched 1; targeted mutation 1, Brandon J Wainwright
• MGI ID: MGI:2675356
• Synonyms: Ptc1^lox, Ptch1^c, Ptch1^flox, Ptch1^neo
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm1Bjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85040
• Parent Cell Line: C1368 (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by a single upstream loxP site in intron 2 and an FRT-neo-FRT-loxP cassette in intron 3. Mice carrying this allele were used to generate Ptch^tm1.1Bjw. (J:85040)

Disease models

Expression

In Mice Carrying this Mutation:	76 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptch1^tm1Bjw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:85040 Ellis T, et al., Patched 1 conditional null allele in mice. Genesis. 2003 Jul;36(3):158-61
• All: 75 reference(s)