Pgia39^DBA/2Crl
QTL Variant Detail

Summary

• QTL variant: Pgia39^DBA/2Crl
• Name: proteoglycan induced arthritis 39; DBA/2Crl
• MGI ID: MGI:2675330
• QTL: Pgia39 Location: ChrX:161474380-161474529 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: DBA/2Crl

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Heterozygosity at Pgia6 in conjunction with DBA/2Crl-derived alleles at Pgia39 conferred lower arthritis onset and incidence (susceptibility).

Pgia39 interacts with Pgia26 on chromosome 3. Animals homozygosous for BALB/cCrl alleles at Pgia26 and homozygous for DBA/2Crl alleles at Pgia39 exhibit increased arthritis onset scores.

Pgia39 interacts with Pgia6 on chromosome 10. Animals homozygosous for BALB/cCrl or DBA/2Crl alleles at Pgia6 and homozygous for DBA/2Crl alleles at Pgia39 exhibit increased arthritis onset scores.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:84150

Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

The authors cite the following marker as having been previously mapped; however, differing parental strains were used in the previous map studies. We have renamed the QTL as follows:

The authors refer to Pgia25 on mouse chromosome X. This QTL was originally mapped using (BALB/cCrl xDBA/1J)F2 mice in J:82018. We have renamed this QTL, mapped here using (BALB/cCrl x DBA/2Crl)F2 mice, as Pgia39. This QTL maps to mouse chromosome X at DXMit5 with LOD=3.0 for disease onset for all F2 mice. The Pgia39 interval spans 67-72cMs on chr X.

Interaction was detected between Pgia6 on mouse Chromosome 10 and Pgia39 on mouse Chromosome X. Heterozygosity at Pgia6 in conjunction with DBA/2Crl-derived allele at Pgia39 conferred lower arthritis onset and incidence (susceptibility).

References

• Original: J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
• All: 1 reference(s)