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Targeted Allele Detail
Symbol: Akt1tm1Hem
Name: thymoma viral proto-oncogene 1; targeted mutation 1, Brian A Hemmings
MGI ID: MGI:2675202
Synonyms: Akt1-, Pkbalpha-
Gene: Akt1  Location: Chr12:112653821-112674884 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
Structural abnormalities of E14 Akt1tm1Hem/Akt1tm1Hem mouse placenta

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:85181
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing lacZ and neo was inserted into exon 1 at the start codon via homologous recombination. The insertion deleted the coding region of exon 1 which encodes 15 N-terminal residues. Endogenous protein was undetected by Western blot analysis of homozygous mutant heart tissue. (J:85181)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:  24 strains or lines available
Original:  J:85181 Yang ZZ, et al., Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory