About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Rasgrp1lag
Spontaneous Allele Detail
Nomenclature
Symbol: Rasgrp1lag
Name: RAS guanyl releasing protein 1; lymphoproliferation autoimmunity glomerulonephritis
MGI ID: MGI:2675033
Gene: Rasgrp1  Location: Chr2:117279993-117343001 bp, - strand  Genetic Position: Chr2, 59.19 cM
Mutation
origin
Strain of Origin:  129
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsThe spontaneous mutation that arose on a 129 background results in the generation of 2 aberrantly spliced transcripts that lack exon 4 and are putatively translated into nonfunctional polypeptides. The mutation suppresses the use of the splice donor site located at the beginning of intron 3 and enables the utilization of cryptic splice sites located in intron 3 resulting in the splicing of intron 3 to exon 5. (J:85189)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasgrp1 Mutation:  5 strains or lines available
References
Original:  J:85189 Layer K, et al., Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity. 2003 Aug;19(2):243-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory