Rasgrp1^lag
Spontaneous Allele Detail

Summary

• Symbol: Rasgrp1^lag
• Name: RAS guanyl releasing protein 1; lymphoproliferation autoimmunity glomerulonephritis
• MGI ID: MGI:2675033
• Gene: Rasgrp1 Location: Chr2:117110464-117173358 bp, - strand Genetic Position: Chr2, 59.19 cM
• Alliance: Rasgrp1^lag page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: The spontaneous mutation that arose on a 129 background results in the generation of 2 aberrantly spliced transcripts that lack exon 4 and are putatively translated into nonfunctional polypeptides. The mutation suppresses the use of the splice donor site located at the beginning of intron 3 and enables the utilization of cryptic splice sites located in intron 3 resulting in the splicing of intron 3 to exon 5. (J:85189)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrp1 Mutation: 55 strains or lines available

References

• Original: J:85189 Layer K, et al., Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity. 2003 Aug;19(2):243-55
• All: 1 reference(s)