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Spontaneous Allele Detail
Symbol: Rasgrp1lag
Name: RAS guanyl releasing protein 1; lymphoproliferation autoimmunity glomerulonephritis
MGI ID: MGI:2675033
Gene: Rasgrp1  Location: Chr2:117279993-117343001 bp, - strand  Genetic Position: Chr2, 59.19 cM
Strain of Origin:  129
Allele Type:    Spontaneous
Mutation:    Other
Mutation detailsThe spontaneous mutation that arose on a 129 background results in the generation of 2 aberrantly spliced transcripts that lack exon 4 and are putatively translated into nonfunctional polypeptides. The mutation suppresses the use of the splice donor site located at the beginning of intron 3 and enables the utilization of cryptic splice sites located in intron 3 resulting in the splicing of intron 3 to exon 5. (J:85189)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasgrp1 Mutation:  5 strains or lines available
Original:  J:85189 Layer K, et al., Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity. 2003 Aug;19(2):243-55
All:  1 reference(s)

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MGI 5.21
The Jackson Laboratory