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Targeted Allele Detail
Symbol: Mogtm1Dpd
Name: myelin oligodendrocyte glycoprotein; targeted mutation 1, Danielle Pham-Dinh
MGI ID: MGI:2675017
Synonyms: MOG-
Gene: Mog  Location: Chr17:37321635-37334290 bp, - strand  Genetic Position: Chr17, 19.16 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:85155
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing lacZ and neo was inserted into exon 1 seven bp upstream of the start codon. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of homozygous mutant mice. The lacZ expression pattern recapitulated that of the endogenous gene. (J:85155)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mog Mutation:  55 strains or lines available
Original:  J:85155 Delarasse C, et al., Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest. 2003 Aug;112(4):544-53
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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