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Bcl10tm1Swm
Targeted Allele Detail
Nomenclature
Symbol: Bcl10tm1Swm
Name: B cell leukemia/lymphoma 10; targeted mutation 1, Stephan W Morris
MGI ID: MGI:2674989
Synonyms: Bcl10-
Gene: Bcl10  Location: Chr3:145922804-145934356 bp, + strand  Genetic Position: Chr3, 71.03 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85147
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3, which encodes the majority of the CARD domain, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of whole cell lysates of bone marrow, thymus, lymph node, and spleen obtained from homozygous mutant mice. (J:85147)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl10 Mutation:  8 strains or lines available
References
Original:  J:85147 Xue L, et al., Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol. 2003 Sep;4(9):857-65
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory