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Thegtm1Wen
Targeted Allele Detail
Nomenclature
Symbol: Thegtm1Wen
Name: testicular haploid expressed gene; targeted mutation 1, Wolfgang Engel
MGI ID: MGI:2674963
Synonyms: Th14-
Gene: Theg  Location: Chr10:79576379-79587331 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband B5-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85175
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsExons 4, 5, 6, and 7 were deleted by homologous recombination of neo cassette. The targeted region encoded amino acids 137 through 376 of the C-terminal. Mutant transcript consisting of exons 1 and 2 spliced to the neo cassette was detected by RT-PCR analysis. Immunotstaining revealed that mutant protein was produced and that it localized to the cytosol of round spermatids in contrast to the wild-type protein which predominantly localizes to the nucleus. (J:85175)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Theg Mutation:  4 strains or lines available
References
Original:  J:85175 Mannan AU, et al., Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. Biol Reprod. 2003 Sep;69(3):788-96
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory