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Targeted Allele Detail
Symbol: Pgrtm2Omc
Name: progesterone receptor; targeted mutation 2, Orla M Conneely
MGI ID: MGI:2674932
Synonyms: PRBKO-
Gene: Pgr  Location: Chr9:8900419-8965425 bp, + strand  Genetic Position: Chr9, 2.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:85196
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsTo eliminate the translation of isoform B, the start codon of isoform B was mutated to encode leucine (ATG to CTG). A single loxP site remained in an intron after a floxed selection cassette was excised via cre mediated recombination. While isoform B was undetected by Western blot analysis of homozygous mutant uterine extracts, the presence of isoform A was confirmed. (J:85196)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  9 strains or lines available
Original:  J:85196 Mulac-Jericevic B, et al., Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9744-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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