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Cacna1ctm3Hfm
Targeted Allele Detail
Nomenclature
Symbol: Cacna1ctm3Hfm
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 3, Franz Hofmann
MGI ID: MGI:2674119
Synonyms: Cav1.2L2, L2
Gene: Cacna1c  Location: Chr6:118587240-119196418 bp, - strand  Genetic Position: Chr6, 55.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66242
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 14 and 15 were left flanked by single loxP sites. This allele was generated using ES cells that were also used to generate Cacna1ctm2Hfm. (J:66242)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:  7 strains or lines available
References
Original:  J:66242 Seisenberger C, et al., Functional embryonic cardiomyocytes after disruption of the L-type alpha 1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem. 2000 Dec 15;275(50):39193-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory