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Cacna1ctm2Hfm
Targeted Allele Detail
Nomenclature
Symbol: Cacna1ctm2Hfm
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 2, Franz Hofmann
MGI ID: MGI:2674114
Synonyms: L1, Line B
Gene: Cacna1c  Location: Chr6:118587240-119196418 bp, - strand  Genetic Position: Chr6, 55.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66242
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 14 and 15, which together encode the transmembrane IIS5 segment and the pore in repeat II, were flanked by loxP sites and subsequently excised in vitro cre-mediated recombination prior to germline transmission. Though RT-PCR revealed aberrant transcript in which exon 13 had spliced to a point within intron 16, no protein was detected in the hearts of homozygous mutant embryos by Western blot analysis. (J:66242)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:  60 strains or lines available
References
Original:  J:66242 Seisenberger C, et al., Functional embryonic cardiomyocytes after disruption of the L-type alpha 1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem. 2000 Dec 15;275(50):39193-9
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory