Cacna1c^tm1Hfm
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1Hfm
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Franz Hofmann
• MGI ID: MGI:2674113
• Synonyms: Line A
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1Hfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66242
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a neo cassette preceded by stop codons into each reading frame. Normal transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:66242)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 141 strains or lines available

References

• Original: J:66242 Seisenberger C, et al., Functional embryonic cardiomyocytes after disruption of the L-type alpha 1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem. 2000 Dec 15;275(50):39193-9
• All: 2 reference(s)