P2ry12^tm1Pcon
Targeted Allele Detail

Summary

• Symbol: P2ry12^tm1Pcon
• Name: purinergic receptor P2Y, G-protein coupled 12; targeted mutation 1, Pamela B Conley
• MGI ID: MGI:2674084
• Synonyms: P2Y12^-
• Gene: P2ry12 Location: Chr3:59123693-59170292 bp, - strand Genetic Position: Chr3, 29.01 cM
• Alliance: P2ry12^tm1Pcon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84917
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire open reading frame was replaced with a neomycin selection cassette inserted by homologous recombination. (J:84917)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry12 Mutation: 41 strains or lines available

References

• Original: J:84917 Andre P, et al., P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest. 2003 Aug;112(3):398-406
• All: 32 reference(s)