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P2ry12tm1Pcon
Targeted Allele Detail
Nomenclature
Symbol: P2ry12tm1Pcon
Name: purinergic receptor P2Y, G-protein coupled 12; targeted mutation 1, Pamela B Conley
MGI ID: MGI:2674084
Synonyms: P2Y12-
Gene: P2ry12  Location: Chr3:59216272-59262871 bp, - strand  Genetic Position: Chr3, 29.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84917
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire open reading frame was replaced with a neomycin selection cassette inserted by homologous recombination. (J:84917)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2ry12 Mutation:  19 strains or lines available
References
Original:  J:84917 Andre P, et al., P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest. 2003 Aug;112(3):398-406
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory