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Targeted Allele Detail
Symbol: Tlr2tm1Kir
Name: toll-like receptor 2; targeted mutation 1, Carsten J Kirschning
MGI ID: MGI:2674036
Synonyms: Ly105, TLR2-
Gene: Tlr2  Location: Chr3:83836272-83841767 bp, - strand  Genetic Position: Chr3, 37.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:85323
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding the extracellular domain and a portion of the transmembrane domain was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of peritoneal macrophages obtained from homozygous mutant mice. (J:85323, J:130011)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tlr2 Mutation:  35 strains or lines available
Original:  J:85323 Wooten RM, et al., Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol. 2002 Jan 1;168(1):348-55
All:  278 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory