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Egfrtm2(EGFR)Wag
Targeted Allele Detail
Nomenclature
Symbol: Egfrtm2(EGFR)Wag
Name: epidermal growth factor receptor; targeted mutation 2, Erwin F Wagner
MGI ID: MGI:2673586
Synonyms: hEGFRKI
Gene: Egfr  Location: Chr11:16752203-16913907 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84870
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Egfrtm2(EGFR)Wag expresses 1 gene
 
Mutation detailsFloxed human cDNA encoding EGFR was inserted at the endogenous locus via homologous recombination. A RSV-neo cassette was inserted downstream of the human sequence. While endogenous levels of the human transcript were detected in brain tissue by RNAse protection, hypomorphic expression was observed in bone and epithelial tissue, putatively due to an effect of the downstream neo cassette. (J:84870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  14 strains or lines available
References
Original:  J:84870 Sibilia M, et al., Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development. 2003 Oct;130(19):4515-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory