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Fancd2tm1Hou
Targeted Allele Detail
Nomenclature
Symbol: Fancd2tm1Hou
Name: Fanconi anemia, complementation group D2; targeted mutation 1, Scott Houghtaling
MGI ID: MGI:2673422
Synonyms: Fancd2-
Gene: Fancd2  Location: Chr6:113531682-113597017 bp, + strand  Genetic Position: Chr6, 52.78 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details220 bp encompassing exons 26 and 27 were replaced with a floxed neo-ura cassette. While RT-PCR analysis of homozygous mutant mice showed transcript lacking the targeted exons, neither normal or mutant protein arising from the detected transcript was detected by Western blot analysis. (J:84892)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancd2 Mutation:  53 strains or lines available
References
Original:  J:84892 Houghtaling S, et al., Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev. 2003 Aug 15;17(16):2021-35
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory