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Bcl2l1tm1Cant
Targeted Allele Detail
Nomenclature
Symbol: Bcl2l1tm1Cant
Name: BCL2-like 1; targeted mutation 1, Harvey Cantor
MGI ID: MGI:2672833
Synonyms: Bcl-xgamma-
Gene: Bcl2l1  Location: Chr2:152780668-152831728 bp, - strand  Genetic Position: Chr2, 75.41 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77507
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 4 which encodes the carboxy terminal of the gamma isoform was replaced with a single loxP site after a floxed neomycin selection cassette was excised via cre mediated recombination. RT-PCR analysis of homozygous mutant T cells identified transcript encoding the L isoform in the absence of transcript encoding the gamma isoform. (J:77507)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l1 Mutation:  120 strains or lines available
References
Original:  J:77507 Ye Q, et al., T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 1;196(1):87-95
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory