Runx1t1^tm1Buch
Targeted Allele Detail

Summary

• Symbol: Runx1t1^tm1Buch
• Name: RUNX1 translocation partner 1; targeted mutation 1, Frank Buchholz
• MGI ID: MGI:2671472
• Synonyms: ETO^X
• Gene: Runx1t1 Location: Chr4:13743436-13893649 bp, + strand Genetic Position: Chr4, 5.88 cM, cytoband A
• Alliance: Runx1t1^tm1Buch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68499
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Other
• Mutation details: A floxed neo cassette was inserted into intron 1, 893 bp upstream of exon 2. This allele, in combination with allele Runx1^tm1Buch in the same cells was used for the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1t1 Mutation: 35 strains or lines available

References

• Original: J:68499 Buchholz F, et al., Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug;1(2):133-9
• All: 1 reference(s)