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Targeted Allele Detail
Symbol: Runx1t1tm1Buch
Name: runt-related transcription factor 1; translocated to, 1 (cyclin D-related); targeted mutation 1, Frank Buchholz
MGI ID: MGI:2671472
Synonyms: ETOX
Gene: Runx1t1  Location: Chr4:13743436-13893649 bp, + strand  Genetic Position: Chr4, 5.88 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:68499
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutation:    Other
Mutation detailsA floxed neo cassette was inserted into intron 1, 893 bp upstream of exon 2. This allele was initially generated for use in the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1t1 Mutation:  9 strains or lines available
Original:  J:68499 Buchholz F, et al., Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug;1(2):133-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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