Ctsc^tm1Ley
Targeted Allele Detail

Summary

• Symbol: Ctsc^tm1Ley
• Name: cathepsin C; targeted mutation 1, Timothy J Ley
• MGI ID: MGI:2671139
• Synonyms: DPP-1^-, DPP1^-, DPPI-
• Gene: Ctsc Location: Chr7:87927293-87960096 bp, + strand Genetic Position: Chr7, 49.11 cM, cytoband D3-E1.1
• Alliance: Ctsc^tm1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77312
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An in-frame lacZ gene and neomycin selection cassette were inserted just downstream of the transcription initiation site. Activity assays demonstrated that no functional protein is made from this allele in homozygous mice. No beta-galactosidase is expressed from this allele. (J:77312)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsc Mutation: 36 strains or lines available

References

• Original: J:77312 Pham CT, et al., Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8627-32
• All: 29 reference(s)