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Targeted Allele Detail
Symbol: Tnfsf14tm1Kpf
Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Klaus Pfeffer
MGI ID: MGI:2671122
Synonyms: LIGHT -
Gene: Tnfsf14  Location: Chr17:57189492-57194189 bp, - strand  Genetic Position: Chr17, 29.71 cM, cytoband D-E1
Germline Transmission:  Earliest citation of germline transmission: J:77250
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from activated splenocytes of homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:77250)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf14 Mutation:  16 strains or lines available
Original:  J:77250 Scheu S, et al., Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med. 2002 Jun 17;195(12):1613-24
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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