Ptx3^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Ptx3^tm1Zuk
• Name: pentraxin related gene; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2670952
• Synonyms: Ptx3 -
• Gene: Ptx3 Location: Chr3:66127331-66133226 bp, + strand Genetic Position: Chr3, 30.25 cM
• Alliance: Ptx3^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76877
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 1 and 2 by homologous recombination. The deleted region encodes the initiation codon and signal peptide for secretion of the protein, so the mutation is predicted to be a null allele. (J:76877)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptx3 Mutation: 23 strains or lines available

References

• Original: J:76877 Varani S, et al., Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. Mol Endocrinol. 2002 Jun;16(6):1154-67
• All: 10 reference(s)