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Thratm3Jas
Targeted Allele Detail
Nomenclature
Symbol: Thratm3Jas
Name: thyroid hormone receptor alpha; targeted mutation 1, Jacques Samarut
MGI ID: MGI:2670368
Synonyms: TRalpha7
Gene: Thra  Location: Chr11:98740638-98769006 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84537
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA loxP flanked cassette containing neo and tk genes replaced a 257 bp fragment of intron 7, eliminating a portion of the internal promoter that drives expression of two short isoforms, TRdeltaalpha1 and TRdeltaalpha2. The floxed selection genes were excised prior to germline transmission. Whereas wild-type levels of transcript encoding the two longer isoforms, TRalpha1 and TRalpha2, were detected in homozygous mutant mice, the levels of transcript encoding the shorter isoforms were reduced. (J:84537)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  21 strains or lines available
References
Original:  J:84537 Plateroti M, et al., Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development. Mol Cell Biol. 2001 Jul;21(14):4761-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory