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Ro60tm1Woln
Targeted Allele Detail
Nomenclature
Symbol: Ro60tm1Woln
Name: Ro60, Y RNA binding protein; targeted mutation 1, Sandra L Wolin
MGI ID: MGI:2670227
Synonyms: Ro-/-
Gene: Ro60  Location: Chr1:143750790-143777063 bp, - strand  Genetic Position: Chr1, 62.54 cM
Glomerulonephritis in Ro60tm1Woln/Ro60tm1Woln mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84627
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetectable by Western blot analysis of homozygous mutant brain extracts. (J:84627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ro60 Mutation:  4 strains or lines available
References
Original:  J:84627 Xue D, et al., A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7503-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory