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Vti1btm1Gfvm
Targeted Allele Detail
Nomenclature
Symbol: Vti1btm1Gfvm
Name: vesicle transport through interaction with t-SNAREs 1B; targeted mutation 1, Gabriele Fischer von Mollard
MGI ID: MGI:2670119
Synonyms: vti1b-
Gene: Vti1b  Location: Chr12:79156017-79172667 bp, - strand  Genetic Position: Chr12, 35.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84574
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4, which encodes the SNARE motif, was disrupted by the insertion of a neomycin selection cassette. Neither normal transcript nor normal protein was detected in homozygous mutant mice by Northern and Western blot analyses. (J:84574)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 33 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vti1b Mutation:  8 strains or lines available
References
Original:  J:84574 Atlashkin V, et al., Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol Cell Biol. 2003 Aug;23(15):5198-207
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory