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Mbl1tm1.1Mnz
Targeted Allele Detail
Nomenclature
Symbol: Mbl1tm1.1Mnz
Name: mannose-binding lectin (protein A) 1; targeted mutation 1.1, Michel C Nussenzweig
MGI ID: MGI:2670117
Synonyms: MBL-A-
Gene: Mbl1  Location: Chr14:41151456-41158959 bp, + strand  Genetic Position: Chr14, 22.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84540
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed neomycin selection cassette that replaced all of exons 2 and 3 and a portion of exon 4 in Mbl1tm1Mnz was excised from the germline via cre mediated recombination. Normal transcript was undetected by Northern blot analysis of total RNA obtained from thioglycolate-stimulated livers of homozygous mutant mice. (J:84540)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbl1 Mutation:  15 strains or lines available
References
Original:  J:84540 Lee SJ, et al., Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice. Mol Cell Biol. 2002 Dec;22(23):8199-203
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory