About   Help   FAQ
Mbl1tm1.1Mnz
Targeted Allele Detail
Nomenclature
Symbol: Mbl1tm1.1Mnz
Name: mannose-binding lectin (protein A) 1; targeted mutation 1.1, Michel C Nussenzweig
MGI ID: MGI:2670117
Synonyms: MBL-A-
Gene: Mbl1  Location: Chr14:41151456-41158959 bp, + strand  Genetic Position: Chr14, 22.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84540
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed neomycin selection cassette that replaced all of exons 2 and 3 and a portion of exon 4 in Mbl1tm1Mnz was excised from the germline via cre mediated recombination. Normal transcript was undetected by Northern blot analysis of total RNA obtained from thioglycolate-stimulated livers of homozygous mutant mice. (J:84540)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbl1 Mutation:  16 strains or lines available
References
Original:  J:84540 Lee SJ, et al., Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice. Mol Cell Biol. 2002 Dec;22(23):8199-203
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory