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Targeted Allele Detail
Symbol: Btrctm1Kin
Name: beta-transducin repeat containing protein; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:2669949
Synonyms: Beta-TrCP1-
Gene: Btrc  Location: Chr19:45363734-45530013 bp, + strand  Genetic Position: Chr19, 38.75 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:84639
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA isolated from the testes of homozygous mutant mice. (J:84639)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btrc Mutation:  40 strains or lines available
Original:  J:84639 Nakayama K, et al., Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8752-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory