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Ptstm1Ich
Targeted Allele Detail
Nomenclature
Symbol: Ptstm1Ich
Name: 6-pyruvoyl-tetrahydropterin synthase; targeted mutation 1, Hiroshi Ichinose
MGI ID: MGI:2669870
Gene: Pts  Location: Chr9:50521617-50528641 bp, - strand  Genetic Position: Chr9, 27.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84764
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. Normal transcript was undetected by Northern blot analysis of homozygous mutant liver and brain tissue. (J:84764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pts Mutation:  6 strains or lines available
References
Original:  J:84764 Sumi-Ichinose C, et al., Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem. 2001 Nov 2;276(44):41150-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory