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Neurod6tm1(cre)Kan
Targeted Allele Detail
Nomenclature
Symbol: Neurod6tm1(cre)Kan
Name: neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:2668659
Synonyms: Math2/Cre, Neurod6-cre, Neurod6/Cre, NexCre, NEX-Cre
Gene: Neurod6  Location: Chr6:55677822-55681263 bp, - strand  Genetic Position: Chr6, 27.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62118
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a cassette containing cre recombinase followed by a neomycin resistance gene in exon 2. The endogenous promoter drove expression of cre in the granule cells of the hippocampus. (J:62118, J:117061)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurod6     Summary of all recombinase alleles driven by Neurod6. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurod6 Mutation:  13 strains or lines available
References
Original:  J:62118 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci. 2000 May 15;20(10):3714-24
All:  185 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory