Grb10^{Gt(Betageo)1Ward}
Gene trapped Allele Detail

Summary

• Symbol: Grb10^{Gt(Betageo)1Ward}
• Name: growth factor receptor bound protein 10; gene trap 1, Andrew Ward
• MGI ID: MGI:2668436
• Synonyms: Grb10 delta2-4
• Gene: Grb10 Location: Chr11:11880499-11987428 bp, - strand Genetic Position: Chr11, 7.15 cM
• Alliance: Grb10^{Gt(Betageo)1Ward} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84425
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The insertion of a gene trap cassette containing Beta-geo replaced ~36 kb of genomic sequence including exons 2 through 4. Transcript was undetected by Northern blot analysis of homozygous mutant mice using a probe corresponding to exon 18, common to all known splice variants. (J:84425)

Disease models

Expression

In Mice Carrying this Mutation:	74 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb10 Mutation: 53 strains or lines available

References

• Original: J:84425 Charalambous M, et al., Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8292-7
• All: 9 reference(s)