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Gene trapped Allele Detail
Symbol: Grb10Gt(Betageo)1Ward
Name: growth factor receptor bound protein 10; gene trap 1, Andrew Ward
MGI ID: MGI:2668436
Synonyms: Grb10 delta2-4
Gene: Grb10  Location: Chr11:11930508-12038683 bp, - strand  Genetic Position: Chr11, 7.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:84425
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
Mutation detailsThe insertion of a gene trap cassette containing Beta-geo replaced ~36 kb of genomic sequence including exons 2 through 4. Transcript was undetected by Northern blot analysis of homozygous mutant mice using a probe corresponding to exon 18, common to all known splice variants. (J:84425)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb10 Mutation:  30 strains or lines available
Original:  J:84425 Charalambous M, et al., Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8292-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory