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Smad2tm2.1Rob
Targeted Allele Detail
Nomenclature
Symbol: Smad2tm2.1Rob
Name: SMAD family member 2; targeted mutation 2.1, Elizabeth J Robertson
MGI ID: MGI:2668416
Synonyms: Smad2CD
Gene: Smad2  Location: Chr18:76241580-76310963 bp, + strand  Genetic Position: Chr18, 51.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84300
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon was excised via in vivo cre mediated recombination. Western blot analysis of homozygous mutant mice confirmed the absence of normal protein. (J:84300)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  16 strains or lines available
References
Original:  J:84300 Vincent SD, et al., Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003 Jul 1;17(13):1646-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory