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Bard1tm1Thl
Targeted Allele Detail
Summary
Symbol: Bard1tm1Thl
Name: BRCA1 associated RING domain 1; targeted mutation 1, Thomas Ludwig
MGI ID: MGI:2668394
Synonyms: Bard1-
Gene: Bard1  Location: Chr1:71066690-71142300 bp, - strand  Genetic Position: Chr1, 35.67 cM
Alliance: Bard1tm1Thl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84329
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame in exon 1 (amino acids 1-46) was replaced with a hygromycin resistance-EGFP fusion gene. Western blot analysis of E9.5 homozygous embryos proved the absence of gene product. (J:84329)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bard1 Mutation:  54 strains or lines available
References
Original:  J:84329 McCarthy EE, et al., Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol. 2003 Jul;23(14):5056-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory