Rock2^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Rock2^tm1Sna
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2668391
• Synonyms: rockII^-, ROCK-II^-
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84386
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3, encoding part of the kinase domain, was replaced with genes for beta-galactosidase and neomycin resistance. Analysis by Western blot confirmed the absence of gene product. (J:84386)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 58 strains or lines available

References

• Original: J:84386 Thumkeo D, et al., Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol. 2003 Jul;23(14):5043-55
• All: 6 reference(s)