Gjc2^tm1Paul
Targeted Allele Detail

Summary

• Symbol: Gjc2^tm1Paul
• Name: gap junction protein, gamma 2; targeted mutation 1, David L Paul
• MGI ID: MGI:2668351
• Synonyms: Cx47 KO
• Gene: Gjc2 Location: Chr11:59066394-59074039 bp, - strand Genetic Position: Chr11, 37.05 cM
• Alliance: Gjc2^tm1Paul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84338
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of the single coding exon removing the sequences encoding the N-terminus and all four transmembrane domains. Northern blot analysis demonstrated the absence of mRNA and loss of the corresponding protein was confirmed by Western blot. (J:84338)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjc2 Mutation: 21 strains or lines available

References

• Original: J:84338 Menichella DM, et al., Connexins are critical for normal myelination in the CNS. J Neurosci. 2003 Jul 2;23(13):5963-73
• All: 6 reference(s)