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Grik5tm1Cont
Targeted Allele Detail
Nomenclature
Symbol: Grik5tm1Cont
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2); targeted mutation 1, Anis Contractor
MGI ID: MGI:2668206
Synonyms: KA2-
Gene: Grik5  Location: Chr7:25009849-25072346 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81742
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing two full exons and a portion of a third, collectively encoding membrane domains I and II, were replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by immunohistochemical analysis of homozygous mutant hippocampal sections. (J:81742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik5 Mutation:  27 strains or lines available
References
Original:  J:81742 Contractor A, et al., Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003 Jan 15;23(2):422-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory