Ncstn^tm1Pcw
Targeted Allele Detail

Summary

• Symbol: Ncstn^tm1Pcw
• Name: nicastrin; targeted mutation 1, Philip C Wong
• MGI ID: MGI:2667524
• Synonyms: NCT^-
• Gene: Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Ncstn^tm1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 9 and 10 were replaced with a neomycin selection cassette. (J:83376)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncstn Mutation: 33 strains or lines available

References

• Original: J:83376 Li T, et al., Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J Neurosci. 2003 Apr 15;23(8):3272-7
• All: 4 reference(s)