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Targeted Allele Detail
Symbol: Spentm1Hon
Name: spen family transcription repressor; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:2667509
Synonyms: MINT-
Gene: Spen  Location: Chr4:141195201-141265908 bp, - strand  Genetic Position: Chr4, 74.26 cM, cytoband E1
Alliance: Spentm1Hon page
Germline Transmission:  Earliest citation of germline transmission: J:82332
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 12, upstream of sequence encoding the MSXB domain. Truncated transcript was identified by Northern blot analysis of homozygous mice at E12.5. (J:82332)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Spen Mutation:  89 strains or lines available
Original:  J:82332 Kuroda K, et al., Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 2003 Feb;18(2):301-12
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory