About   Help   FAQ
Spentm1Hon
Targeted Allele Detail
Summary
Symbol: Spentm1Hon
Name: spen family transcription repressor; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:2667509
Synonyms: MINT-
Gene: Spen  Location: Chr4:141195201-141265908 bp, - strand  Genetic Position: Chr4, 74.26 cM, cytoband E1
Alliance: Spentm1Hon page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82332
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 12, upstream of sequence encoding the MSXB domain. Truncated transcript was identified by Northern blot analysis of homozygous mice at E12.5. (J:82332)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Spen Mutation:  89 strains or lines available
References
Original:  J:82332 Kuroda K, et al., Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 2003 Feb;18(2):301-12
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory