About   Help   FAQ
Ahrd
Allele Detail
Nomenclature
Symbol: Ahrd
Name: aryl-hydrocarbon receptor; d variant
MGI ID: MGI:2667196
Synonyms: ah, Ahd, Ahhn, Ahk, AhRd, in
Gene: Ahr  Location: Chr12:35497979-35534989 bp, - strand  Genetic Position: Chr12, 15.78 cM
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Not Applicable
Mutation:    Nucleotide substitutions
 
Mutation detailsThis allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. (J:15153, J:17460, J:22144)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 20 strains available      Cell Lines: 0 lines available
Carrying any Ahr Mutation:  76 strains or lines available
Notes

Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains

References
Original:  J:26440 Schmid FA, et al., Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res. 1967 Mar;27(3):558-62
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory