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Fras1tm1Chpk
Targeted Allele Detail
Nomenclature
Symbol: Fras1tm1Chpk
Name: Fraser syndrome 1 homolog (human); targeted mutation 1, George Chalepakis
MGI ID: MGI:2667194
Synonyms: Fras1-
Gene: Fras1  Location: Chr5:96373955-96784728 bp, + strand  Genetic Position: Chr5, 47.29 cM
Defective septation of right lung lobes in Fras1tm1Chpk/Fras1tm1Chpk embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83746
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ/neo cassette was inserted into exon 6 of the gene. Immunofluorescence staining failed to detect protein in homozygous mutant mice. (J:83746)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fras1 Mutation:  5 strains or lines available
References
Original:  J:83746 Vrontou S, et al., Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice. Nat Genet. 2003 Jun;34(2):209-14
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory