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Targeted Allele Detail
Symbol: Stap2tm1Ayos
Name: signal transducing adaptor family member 2; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:2667181
Synonyms: STAP-2
Gene: Stap2  Location: Chr17:55997081-56005570 bp, - strand  Genetic Position: Chr17, 29.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:82584
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4 through 13, encoding the carboxyl portion of the PH domain and the entire SH2 domain, was replaced with a neomycin selection cassette. Northern blot analysis of homozygous mutant mice indicated an absence of transcript. (J:82584)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stap2 Mutation:  7 strains or lines available
Original:  J:82584 Minoguchi M, et al., STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem. 2003 Mar 28;278(13):11182-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory