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Targeted Allele Detail
Symbol: Ikzf1tm1Kast
Name: IKAROS family zinc finger 1; targeted mutation 1, Philippe Kastner
MGI ID: MGI:2667175
Synonyms: IkL
Gene: Ikzf1  Location: Chr11:11685003-11772926 bp, + strand  Genetic Position: Chr11, 7.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:82813
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExon 2, which is common to all known isoforms, was disrupted by the in frame insertion of beta-geo and floxed neo. Full length protein was undetected by Western blot analysis of homozygous mutant bone marrow, spleen, and thymus, though truncated polypeptides, translated from transcripts with aberrant splicing from exon 1 to 3, were identified in the spleen and thymus. Low levels of protein arising from the targeted locus were detected by immunohistochemical analysis of homozygous mutant splenocytes. (J:82813)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf1 Mutation:  5 strains or lines available
Original:  J:82813 Kirstetter P, et al., Ikaros is critical for B cell differentiation and function. Eur J Immunol. 2002 Mar;32(3):720-30
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory