Ikzf1tm1Kast
Targeted Allele Detail
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Symbol: |
Ikzf1tm1Kast |
Name: |
IKAROS family zinc finger 1; targeted mutation 1, Philippe Kastner |
MGI ID: |
MGI:2667175 |
Synonyms: |
IkL |
Gene: |
Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
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Alliance: |
Ikzf1tm1Kast page
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Germline Transmission: |
Earliest citation of germline transmission:
J:82813
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Parent Cell Line: |
P1 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: Exon 2, which is common to all known isoforms, was disrupted by the in frame insertion of beta-geo and floxed neo. Full length protein was undetected by Western blot analysis of homozygous mutant bone marrow, spleen, and thymus, though truncated polypeptides, translated from transcripts with aberrant splicing from exon 1 to 3, were identified in the spleen and thymus. Low levels of protein arising from the targeted locus were detected by immunohistochemical analysis of homozygous mutant splenocytes.
(J:82813)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ikzf1 Mutation: |
30 strains or lines available
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Original: |
J:82813 Kirstetter P, et al., Ikaros is critical for B cell differentiation and function. Eur J Immunol. 2002 Mar;32(3):720-30 |
All: |
17 reference(s) |
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