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Ikzf1tm1Kast
Targeted Allele Detail
Summary
Symbol: Ikzf1tm1Kast
Name: IKAROS family zinc finger 1; targeted mutation 1, Philippe Kastner
MGI ID: MGI:2667175
Synonyms: IkL
Gene: Ikzf1  Location: Chr11:11634980-11722926 bp, + strand  Genetic Position: Chr11, 7.02 cM
Alliance: Ikzf1tm1Kast page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82813
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 2, which is common to all known isoforms, was disrupted by the in frame insertion of beta-geo and floxed neo. Full length protein was undetected by Western blot analysis of homozygous mutant bone marrow, spleen, and thymus, though truncated polypeptides, translated from transcripts with aberrant splicing from exon 1 to 3, were identified in the spleen and thymus. Low levels of protein arising from the targeted locus were detected by immunohistochemical analysis of homozygous mutant splenocytes. (J:82813)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ikzf1tm1Kast
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf1 Mutation:  30 strains or lines available
References
Original:  J:82813 Kirstetter P, et al., Ikaros is critical for B cell differentiation and function. Eur J Immunol. 2002 Mar;32(3):720-30
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory